HSS 2305 Lecture Notes - Lecture 26: Tumor Suppressor Gene, Cancer Stem Cell, Cell Cycle Checkpoint
19 Dec 2016
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Hss2305 lecture 26 molecular mechanisms of cancer. Cancer different kinds of malignant growths that invade adjoining. Uncontrolled growth: division beyond normal limits: 2. Invasion: invasion and intrusion of adjacent tissues: 3. Metastasis: spread to other locations in the body via blood or lymph. Cancer alterations in the dna of a somatic cell: gene expression in cancer cells is altered, cancer cells proliferate in an uncontrolled manner, forming malignant tumors, malignant tumors metastasize secondary tumors https://youtu. be/bdwrzd19swg. Malignant cells not responsive to regulatory cues for growth and division. Capacity for growth and development: normal cell = malignant cell. Regulation of growth and development: normal cell >>> malignant cell inhibitory signals. Different types of cancer cells share a number of similarities: Dna mutations, translocations: abnormal cell cycle checkpoint progression, fail to elicit apoptosis. Mutagenic agents alter genome: carcinogenic chemicals, uv damage. Dna/rna tumor viruses: genes products interfere with cell growth regulation.
