BIOL 3120 Chapter Notes -Bronchoconstriction, Chemokine, Leukotriene
Document Summary
The early response occurs within minutes of allergen exposure and results from the release of histamine (vasodilation), leukotrienes (bronchoconstriction), and prostaglandins (mucus secretion) from local mast cells. Eosinophils play a principal role in the late-phase reaction. Eosinophil chemotactic factor, released by mast cells during the initial reaction, attracts large numbers of eosinophils to the affected site. This leads to degranulation and further release of inflammatory mediators that contribute to the extensive tissue damage typical of the late-phase reaction. Neutrophils, another major participant in late-phase reactions, are attracted to the site of an ongoing type i reaction by neutrophil chemotactic factor released from degranulating mast cells. Late in a type i response, basophils migrate into the dermis of the ear (1) and are activated by.
