BIOL 3051 Chapter Notes - Chapter 11.1: Calcium Channel, Calcium In Biology, Cytoskeleton
24 Apr 2020
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Calcium ions regulate cellular function: na+, k+ & cl- primarily serve an electrogenic role in cell, ca2+ regulates vm & cellular function, normally intracellular [ca2+] is 100nm. Opening of vgccs increase intracellular to high um. Increase in ca2+ triggers range of ca2+ dependent processes: Cellular growth & cytoskeletal remodeling: prolonged elevation of ca2+ is cytotoxic contracted state, calcium concentration tightly regulated. Calcium channel alpha subtypes: hva/ lva, l, n, p/q, t-type, molecular & genetic properties. Role of auxiliary subunits: a2 subunits are good drug targets b/c can chance channel conductance, only hva have axillary units. Inactivation of vgccs: mechanism of activation similar to na/k, all ca channels have voltage dependent ininactivation (vdi) Vdi similar to inactivation gate in na+ channel w/loop. Ca2+ dependent inactivation of calcium channel (cdi: calcium entry creates localized high [ca2+, ca2+ binds to calmodulin (cam) that"s at c-terminal. Binding of ca2+ links n/c terminal which blocks pore.
