BIOL 3051 Chapter Notes - Chapter 11.6: Sucralfate, Alginic Acid, Sodium Bicarbonate
24 Apr 2020
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Non-pharms simultaneously occurring with all this: benefit: faster symptom relief. Severe symptoms: patients with frequent (2+ episodes/week), severe symptoms that impair quality of life, or barrett"s esophagus, standard-dose ppi once daily. Non-pharmacological therapies (1st line of therapy if no alarm symptoms and mild. Main classes: antacids, alginates (gaviscon), h2-antagonists, ppis, motility agents: compare efficacy in terms of symptom relief, esophagitis treatment, and prevention of recurrences. Motility agents cholinergic tone and dopamine: help with increasing motility. Antacids neutralize the acid in the stomach: do not prevent gerd, role limited to on demand use for relief of mild gerd symptoms (<1/week) Motility agents lack evidence, they are off label use, and have more side effects, and we only use them if there is a motility problem. H2ras more effective in decreasing frequency and severity of heartburn symptoms compared to antacids. One can develop dependence within 2-6 weeks of h2ras use.
