BIOL 3051 Chapter Notes - Chapter 11.5: Inflammatory Bowel Disease, Rheumatoid Arthritis, Bone Resorption
24 Apr 2020
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Medications that cause op and their potential mechanisms (need to know): Aromatase inhibitors (letrozole, anastrozole) breast cancer drugs. Bmd and fracture risk; vitamin d metabolism leading to low. Bmd and fracture risk; estrogen concentrations. Prevent estrogen production extremely low blood levels of estrogen bone loss, increased risk of fractures, particularly at. Bmd and fracture risk; bone resorption and bone formation; Reduced activity of the bone-forming cells (enhanced apoptosis of osteoblasts) which may result in bone loss. Increased activity of the cells that break down bone which may. Reduce estrogen and testosterone concentrations the spine and wrist result in bone loss absorption months of therapy of fractures falling equivalent of >=7. 5mg/day starting an alpha adrenergic blocker. Create negative calcium balance via ca secretions and reduced. Dose and duration dependent; rapid bone loss within first 6-12. Dose: prolonged therapy (>3 months/year) at prednisone. Glucocorticoid joint injections, inhalers, skin creams or eye drops. Do not increase the risk of osteoporosis.
