BIOL 2021 Chapter Notes - Chapter 16.7: Filamin, Motor Protein, Cell Cortex
11 Feb 2018
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Arp proteins also create actin webs when they bind to the side of an already existing filament (always branches at a 70 degree angle) Formin: dimeric proteins that nucleate the growth of straight, unbranched filament bundles on the plus end: found in the cell cortex. Thymosin: prevents polymerization by binding to free subunits. Profilin: increases the elongation rate by delivering subunits: if activated at the pm, it makes actin filaments. Thymosin and profiling compete for binding on actin. Tropomyosin: binds to actin and stabilizes the filament. Gelsolin: binds to the plus end and breaks actin filaments. Filamin: cross-links actin filaments to create a network of filaments. Motor proteins bind to cytoskeleton filaments and move along them, using energy from atp. They bind to actin or tubulin, and can carry organelles (generate force contraction) Motor proteins are found in all eukaryotic cells. Myosin family is the largest and most well known family of motor proteins.
