BIOL 2021 Chapter Notes - Chapter 16: Interphase, Protozoa, Cytosol
11 Apr 2017
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Document Summary
Cytoskeleton depends on 3 families of protein filaments: 1) actin filametns, 2) microtubules, 3) intermediate filaments. So, by regulating the local activity of profiling, cells can control the movements of actin subunits from the thymosin bound pool onto filament plus ends. Profiling regulation: profilian phosphorylation, profilan binding to inositol phospholipids, these modifications can decide the sites at which profiling acts. Arp= actin related protein (45% identical to actin) Nucleates actin filament growth from minus end. Can attach to side of another actin filament while remaining bound to the minus end of the filament it has nucleated. Cells in the periventricular region of the brain fail to migrate to the cortex and instead form nodules, causing a syndrome called periventricular heterotopia. Myosin family includes a number of one headed and two headed varieteies all myosins move toward the plus end of an actin filament: exception: myosin vi which moves toward minus end.
