BIOL 2021 Chapter Notes - Chapter 18: Fas Ligand, Programmed Cell Death, Death Domain
11 Apr 2017
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Document Summary
Cell death is not a random process. When activated by the binding fo fas ligand, the death domains on the cytosolic tails of the fas death receptors bind intracellular adaptor proteins. Water soluble component of the mitochondrial electron transport chain. Bcl2 proteins regulate the intrinsic pathway of apoptosis. When an apoptotic stimulus triggers the intrinsic pathway, the pro-apoptotic effector bcl2 family proteins become activated and aggregate to form oligomers in the mitochondrial outer membrane. This induces the release of cytochrome c and other intermembrane proteins by an unknown mechanism. Ex: some extracellular survival signals block apoptosis by inhibiting the synthesis or activity of certain. In response to dna damage that cant be repaired, the tumor suppressor protein p53 accumulates and activates the transcription of genes that encode the bh3 only proteins. These then trigger the intrinsic pathway, eliminating a potentially dangerous cell that could become cancerous.
