BIOL 2021 Lecture Notes - Lecture 18: Fas Ligand, Fas Receptor, Lamin
12 Apr 2016
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Document Summary
We must regulate division, growth, cell survival and death. In adults, cell division must be balanced with cell death. Apoptosis: programmed cell death, but there are other methods for programmed cell death too. 18-1: morphology: cell shrinks b/c cytoskeleton collapses, nuclear envelope disassembles, chromatin condenses and fragments, cell surface blebs; neighbouring cell or macrophage engulfs dying ell. Necrosis: death by accident, cell swells, bursts open, contents spill out and causes inflammatory response b/c body thinks it is being attached. Function in apoptosis: eliminate unwanted cells during development, fig. In adults eliminated damaged cells i. e. dna damage: quality control in development, regulate organ size in adults i. e. liver. Markers of apoptosis: dna is cleaved into small pieces, ptd ser exposed on cell surface that serve as eat me" signals. 3: mitochondrial membrane potential is lost; proteins like cytochrome c come. Mechanisms procaspases are the inactive precursor and they are activated by.
