PSY492H1 Chapter Notes - Chapter 4: Ampa Receptor, Gria1, Dlg4
Document Summary
Chapter 4 generating and stabilizing the trace: post-translation processes. Newly established memory traces are vulnerable to disruption, but over time the traces become stable or. Post-translational processes the processes that chemically modify a protein after its translation (stabilizes memories) How does the ltp-inducing stimulus alter the dynamic of ongoing constitutive ampa trafficking and modify the actin cytoskeleton to rapidly increase number of ampa in psd. Ampa receptor trafficking continuous and regulated by constitutive trafficking processes, this is the movement of. Ltp-inducing stimulus produces synaptic activity which reorganizes constitutive processes to favour increasing number of ampa receptors immobilized in psd (requires delivering receptors to extrasynaptic regions and trapping them in the psd) Delivering ampa receptors ampa receptors delivered to psd in three steps. Ampa receptors can be composed of different subunits (glua1-glua4) under basal conditions they contain glua2 subunits: most of the ampa receptors generally have glua1 subunits (from induction of ltp) Glua1 ampa receptors have phosphorylation sites (ser818, ser831, ser845)
