PSY492H1 Chapter Notes - Chapter 8: Gria1, Tropomyosin Receptor Kinase B, Brain-Derived Neurotrophic Factor
Document Summary
Increase of ca2+ modifies calmodulin to place camkii into an active state. Camkii phosphorylates the tarp stargazin associated with glua1 ampa subunits modification releases stargazin from the plasma membrane so that it can bind to psd-95 proteins and trap the glua1 receptors in the psd. Camkii also phosphorylates glua1 receptors to let them influx calcium. Activate myosin iib motor proteins that cut existing actin filaments into smaller units (to provide building blocks for actin filament strands) Activate other enzymes that phosphorylate limk and thus increase actin polymerization and crosslinkage of actin filaments to make new ones resistant to depolymerization. The consolidation phase centers on processes that synthesize new proteins, transcription and translation inhibitors that do not influence induction or stabilization phase prevent potentiated synapses from enduring for more than about an hour. Activation of transcription + translation depend on sustaining increased calcium levels in dendritic spine and soma, brought about by.
