IMM250H1 Chapter Notes - Chapter 3: Natural Killer Cell, Bacterial Effector Protein, Wound Healing
Document Summary
Chapter 2: innate immunity - the first line of defense. Innate physical & chemical barriers to prevent the penetration of pathogens. Innate mediators (complement proteins) and resident cells (macrophages, dendritic cells) These sense when a barrier is breached; capable of direct killing as well as wound repair. Also sends signals to trigger a rapid innate mechanism (acute inflammatory response) additional effectors ( natural killer cells ) deployed. If this doesn"t work dendritic cells dispatched to regional secondary lymphoid tissues to find and activate lymphocytes. 4 major types of pathogens: viruses, bacteria, fungi and parasites (in order of increasing structural complexity) Parasites further grouped into protozoan parasites (unicellular) and helminths (worms) Virulence factors that facilitate host penetrance and invasion; these are encoded in their chromosomal dna or plasmids; mobile genes that can be transferred from a virulent strain to a non-virulent one. Adhesins allows pathogen to adhere to specific host tissue.
