IMM250H1 Lecture Notes - Lecture 7: Interleukin 13, Innate Immune System, Mhc Class I
Document Summary
Lecture 7: fine-tuning adaptive responses: health vs disease. Th1-mediated immune responses: ifn is a major th1 effector cytokine, promotes defense against intracellular pathogens, this response has 3 major roles, activates macrophages; has 3 requirements. Increase levels of chemical intermediates in phagocytic vesicles enhances microbial killing. Increases mhc class ii expression increasing antigen presentation. Th2-mediated immune response: there are 3 major th2 effector cytokines; il-4, After infection: antigen-induced lymphocyte proliferation (clonal expansion) is normally followed by programmed cell death once pathogen is cleared, memory cells stay behind so if infection happens again you can re-activate cells faster. Leishmaniasis while balb/c mice tend to make weak th1 responses but strong th2 response and were susceptible to development of leishmaniasis. The major histocompatibility complex (mhc: mhc is a large gene complex" with many different genes and many of these genes are involved in immune responses, several of these genes encode the mhc proteins involved in antigen presentation.
