IMM250H1 Lecture Notes - Lecture 6: Minnesota State Highway 7, Cd28, Hematopoietic Stem Cell Transplantation
Document Summary
Lecture 6: ge(cid:374)eratio(cid:374) of the adaptive i(cid:373)(cid:373)u(cid:374)e respo(cid:374)se. Mhc complex and its subsequent display on a host cell surface: only one peptide at a time presented by an mhc molecule, peptide-mhc class i: on all host cells - recognized by. Cd8+ t cells: peptide-mhc class ii: on antigen presenting cells (i. e. dcs, macrophages, b cells) - recognized by. Signal 2: costimulation: dc"s travel from tissue (where injury is) to secondary lymphoid tissues where na ve t cells are found, dcs must be induced to mature by. Pamp/damp detection before they can provide costimulation (only express b7 after activated by. Il-2; key cytokine for full activation of t cells: cd4+ t cells makes its own il-2, th effector makes it for na ve cd8+t cell (so they can turn into tc effector cells) Th and cd40 on the b cell: signal 3: th-derived cytokines control differentiation of the activated b cell and the class of antibody the plasma cells make.
