BIO230H1 Chapter Notes - Chapter 8: Ubiquitin Ligase, Transcriptional Regulation, P53
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BIO230H1 Full Course Notes
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Lecture 8 1) post-translational regulation readings (alberts et al. , custom text) 29-33;107- Many proteins are controlled by covalent modifications that direct them to specific site inside the cell. Cell responds rapidly to changes in environment. Protein can carry post-translational addition to more than one aa. A complex network of protein interactions underlies cell function. Protein interaction maps are useful for identifying the likely function of previously uncharacterized proteins. Some protein can be used as part of different protein complex. In cross species comparisons, proteins displaying similar patterns will likely to have same function. Transcription regulators are brought into play by extracellular signals. Sometimes, information needs to be passed between different cell types by passing through the membrane and ecm. Some ways to control transcription regulators: 1. Protein synthesized only when needed degraded rapidly dso does not accumulate: activation by ligand binding, covalent modification. Camp binds regulatory conf change dissociates the subunit can phosphorylate target protein.
