BIO230H1 Chapter Notes - Chapter 5: Telecommunications Link, Polyadenylation, Transferase
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BIO230H1 Full Course Notes
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Rna polymerase ii phosphorylates the tail (c-terminal domain) Ctd holds a variety of protein nearby so they can rapidly act when needed. Lecture 5 - readings (alberts et al. , custom text) pages 65-71; 116-120. Both ends of eukaryotic mrna are modified: Rna capping is the first modification of eukaryotic pre-mrnas. Phosphatase removed a phosphate from 5" end. Guanyl transferase adds a gmp in a reverse link are (5"to5") A methyl transferase adds a methyl group to guanosine. The 5" help cell distinguish mrna from other type of rna. Capping protein first bind to rnap tail, then as soon as the 5" emerges, it will cap. As polymerase keeps going, the tail is phosphorylated on the ser2 position and ser5 is eventually dephosphorylated . Only fully dephosphorylated form of rnap ii is competent to begin rna synthesis at a promoter. Rna splicing removed intron sequence from ney transcribed pre-mrnas.
