PSYC31H3 Chapter Notes - Chapter 7: Glatiramer Acetate, Information Processing, Optic Neuritis
Document Summary
Frontotemporal lobar degeneration: relative sparing of the posterior regions of the brain, age of onset. Pick"s disease: ftd used to be known as pick"s disease but it is now it"s, risk factors own subtype. Four genes have been associated: microtubule associated protein tau gene (mapt, progranulin gene (pgrn, charged multivesicular body protein 2b gene (chmp2b, valosin containing protein gene (vcp) One study found that prior to the onset of ftd, these patients had a greater than usual incidence of brain trauma: pathophysiology and neuroanatomy. Tau-negative forms of ftd, producing the behavioral variant. Prominent microvascular change and/or severe astrocytic gliosis with or without pick bodies. In pure frontotemporal cases: atrophy in the frontal and temporal neocortex. Limbic system and the corpus striatum are affected but much less than the neocortex: the extent of hippocampus and amygdala involvement varies from case to case. Glucose hypometabolism in frontal and anterior temporal cortices occurs relatively early in the disease process: clinical subtypes.
