BIOC39H3 Chapter Notes -Neutrophil, Lysosome, Histocompatibility
12 Mar 2013
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In bone marrow, pluripotent hsc give rise to common lymphoid progenitor cells. Those clpc that develop into precursor cells that"re commited to become bc. What distinguishes 1 precursor from another is cell-surface markers. Cd34 present on all human hsc pro-b cells: earliest identifiable cells in bc lineage. Divide to produce both more pro-b bc and cells that will go onto develop further. Main event in pro-bc stage: reararngement of. Hc genes, which always comes before lc gene rearrangement. Early pro-b cell stage: joining of d_h and j_h gene segments. Late pro-b cell stage: joining of v_h segment to rearranged dj_h. Rearranged gene is transcribed through to mu. C-region gene, the nearest c gene to rearranged. V region; rna transcript is spliced to produce mrna for the mu heavy chain first type of ig chain made by developing bc. After bc expresses mu chain, its called pre-b cell.
