BIO 1140 Chapter Notes - Chapter 5: Activated Complex, Second Messenger System, Nuclear Receptor
22 Dec 2016
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Set up: choosing signal/signalling molecule: reception: cell receives message from signalling molecule. Depends on # and type of receptor presented on outer membrane. Cell signalling: transduction: interpretation and relay of message. Series of biochemical reactions to relay message: response: cellular response activated. Direct/indirect: direct = direct (fastest), indirect = others: direct cell signalling: signal sent to cells in contact using gap junctions, autocrine and paracrine: messengers leaves the cell and travels short distance. Autocrine: messenger returns to original cell: exocrine: messages released from glands, endocrine signalling: messenger travels through the bloodstream, neural signalling: short/long distances in short time. Messengers arrive to neuronal cell travels down cell via action potential convert back to chemical to be released to next neuronal cell. Change in cell/environment causes cell to send a message via chemical messengers. Proteins must be globular, soluble and carry steroids into endocrine pathway. Allows for messenger to arrive at its desired target.
