BIO 1140 Chapter Notes - Chapter 2: Kinesin, Covalent Bond, Microfilament

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Microfilaments concentrated at outer edge of cell (cell membrane) Provide structure and support (scaffold): allows for positioning+organizing organelles in the cell force for cell movement(flagellum) Contribute to cell division (microtubules and spindle fibres) Dynamic: able to change size, shape and # constantly. Bonds forming fibres must not be covalent (ionic, intermolecular forces and bonds) Largest of the 3 but still small (25nm diameter). Dynamic: microfilaments: very dynamic, intermediate filaments: least flexible. By changing length of polymer: elongating towards one end. They are polymers: monomers of proteins connected end to end. Combo. of these 3 fibres in diff. proportions = diversity in size, shape and mobility of cells. Ex: epithelial (skin) cells will have high proportions of microfilaments to be elastic. Motor proteins(mechanoenzymes) pull on network using atp to transport material. Basic units: tubulin dimers (alpha and beta): globular proteins. Gtp binding site on dimers determine which dimer it is.

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