MICB 202 Chapter Notes - Chapter 3: Viral Envelope, Membrane Fusion Protein, Lipid Bilayer Fusion
Document Summary
Topic 3: orthomyxoviruses segmented, ( ) rna genome, enveloped responsible for influenza (highly contagious, acute respiratory illness) transmitted by respiratory route. Influenza c (7 rna segments) encode and package own polymerase. Only transcribed after virus uncoated in the host cell transcription and replication occurs in the nucleus. 8 segments of single stranded ( ) rna. Six of the segments: code for only one protein. Other two segments: each code for two proteins. 10 genes coded for in total (by 8 ssrna strands) Each ( ) rna genome segment is transcribed by rdrp to synthesize viral mrna. 5" e(cid:374)d of (cid:272)ellular pre-mrna is used as primer. Mrna from the segments that carry two genes are spliced for translation. Ribonucleoproteins (rnps): segments of the genome consist of rna + nucleoprotein (np) Note: np = a complex consisting of a nucleic acid bonded to a protein. Rnp consists of 4 different proteins and rna.
