MICB 202 Chapter Notes - Chapter 1: Dna Virus, Reverse Transcriptase, Orthomyxoviridae
Document Summary
Topic 1: introduction to viruses molecular diversity, properties and pathogenicity. Virus: genetic elements that exist in extracellular (virus particle/virion) or intracellular form. Viral genome surrounded by a capsid (protein coat) and sometimes lipid bilayer (envelope) Intracellular state: reproduction (replication) and adaptation (genetic mutation or variation) Genetic information encoded by dna or rna. Require assistance of living cell for replication. Obligate intracellular parasites dependent on a living host cell for reproduction. Do not grow or form by division. E(cid:454)p(cid:396)essio(cid:374) of ge(cid:374)es (cid:894)(cid:373)ake (cid:373)rna a(cid:374)d use the (cid:272)ell"s (cid:373)a(cid:272)hi(cid:374)e(cid:396)(cid:455) to (cid:373)ake p(cid:396)otei(cid:374)(cid:895) Viral gene products may have toxic effects on host cell metabolism. Host"s i(cid:373)(cid:373)u(cid:374)e s(cid:455)ste(cid:373) (cid:373)a(cid:455) (cid:396)ea(cid:272)t a(cid:374)d dest(cid:396)o(cid:455) i(cid:374)fe(cid:272)ted (cid:272)ells. Expression of host genes may be modified with genetic material of the virus. Host cells may be destroyed by infecting virus. Viral enzymes used as molecular biology tools: dna ligase, reverse transcriptase, rna pol, rnase h.
