BGEN 3020 Chapter Notes - Chapter 4: Prostaglandin E2, Phenytoin, Vasoconstriction

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

If give a person 50% o2 for a period of time, will get superoxide free radicals, which lead to reperfusion injury, esp after giving tpa when trying to rid a damaged thrombus. Oxygentated blood goes back into the damaged cardiac muscle=reperfusion injury. Complication of radiation therapy is cancer (mc cancer from radiation is leukemia, due to hydroxyl free radicals). Fe2+ produces hydroxyl free radicals b/c of the fenton rxn. Mcc drug induced fulminant hepatitis b/c free radicals (esp targets the liver, but also targets the kidneys). Cytochrome p450 in liver metabolizes drugs, and can change drugs into free radicals. Drugs are often changed in the liver to the active metabolite ie phenytoin. Superoxide free radicals can be neutralized with supraoxide dismutase (sod). Glutathione is the end product of the hexose/pentose phosphate shunt and this shunt also generates nadph. Main function is to neutralize free radicals (esp drug free radicals, and free radicals derived from peroxide).