BLD 204 Lecture Notes - Lecture 6: Lipid Peroxidation, Reperfusion Injury, Peroxynitrite
4 Jul 2019
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Document Summary
Types of radicals produced. (np: o2- (oxygen radical, oh (hydroxy-radical, onoo (peroxynitrite radical, lipid peroxide radicals, once formed, lipid peroxide radicals form other peroxides next to them this spirals out of control cell injury. Major mechanisms of free radical damage in cells: lipid peroxidation of membranes. Double bonds of unsaturated fatty acids are attacked by oxygen-derived free radicals. The peroxides are unstable and they react with membrane lipids to both damage them and to form more peroxides. Thus the peroxidation of membranes is self-sustaining and can cause a great deal of damage unless and until free radicals are captured by free radical scavengers such as the vitamin e embedded in the membranes. Also vitamines c&a, and carotene are antioxidants. Major mechanisms of free radical damage in cells: oxidation of proteins. Oxidation of side chains changes function/structure of proteins. Major mechanisms of free radical damage in cells: dna damage. Free radical interaction with thymine causes single-stranded breaks in dna.
