BLD 204 Lecture Notes - Lecture 8: Coagulative Necrosis, Anaerobic Glycolysis, Necrosis
4 Jul 2019
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Document Summary
Ischemia is caused by the reduction of available oxygen, and when it leads to tissue death, you end up with heart attack, stroke, etc. Reperfusion is when blood flow/oxygenation of the tissue is restored - giving clot breaking therapy (tpa) during heart attack and stroke or in transplantation. Leads to a large amount of ros damage: Serum blood tests to detect elevations in the creatine kinase-mb (ck-mb) fraction or in troponin i (tni) or troponin t (tnt) levels top= nl bottom= mi. Mi (np: lean sign: clutching chest = mi, no qrs or t elevation is an indication of infarction, depression which is indication of ischemia, permeable membranes allow leak so we can measure these in serum. Ros reacts with: lipid peroxide radicals - disruption of plasma membranes and organelles. Oxidation of proteins - abnormal folding of proteins and affects enzyme activity. Expression of cytokines and cell adhesion molecules cause accumulation of neutrophils which in turn cause further injury.
