MICR 3230 Chapter 17-18: Chapter 17+18 notes
14 Mar 2016
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25% deaths worldwide associated with communicable diseases & kill 11-12 million/year. More in developing world (less sanitaion & vaccine access) Depend on characterisics of pathogen & how it interacts w. host: mutualisic/commensal. Absence of gut lora = colonizaion of bacteria (lora normally outcompete them: opportunisic. Wouldn"t normally see disease in healthy person: obligate extracellular. Phagocytosis usually enough (macrophages/neutrophils), but also use ab"s, complement, t cells: faculaive intracellular. Survive & replicate in phagocytes (segregated from immune mediators) T cells, adcc, ab"s, complement: obligate intracellular. Combat with cd4+ t cells, cd8+ t cells, adcc, ab"s, complement. Ways pathogens escape immune system: reduce anigenicity. Produces a lot of inefecive ab"s: mimic host (molecular mimicry) Acquiring host membrane molecules (mhc i: suppress/regulate response. Switching type of response (th1/th2: variaion of surface anigens. Epithelial linings of skin & gut, microbiota, low ph. Innate encountered irst, tailored to type of pathogen (prr"s, diferent cell types)
