PCB 4233 Study Guide - Final Guide: Immunoglobulin Heavy Chain, Neutrophil Extracellular Traps, Innate Immune System
Document Summary
Malt defends mucosal surfaces lining of digestive, respiratory and urogenital tracts. C3 convertase of alternative pathway; factor b binds to c3b and is cleaved by factor d opsonin a protein bound to the surface of a pathogen that facilitates phagocytosis. Cr1 complement receptor 1- binds to c3b deposited on microbial surfaces leading to phagocytosis. C5a recruits neutrophils to infection site; most potent anaphylatoxin. C5 protein on activation the soluble fragment initiates assembly of the membrane-attack complex in solution. C6 protein binds to and stabilizes c5b, forms binding site for c7. C7 protein binds to c5b6 and exposes a hydrophobic region that permits attachment to the cell membrane. C8 protein binds to c5b67 and exposes hydrophobic region that inserts into the cell membrane. C9 protein polymerization on the c5b678 complex to form a membrane-spanning channel that disrupts the cell"s integrity and can result in cell death. Cr1 recognizes c3b; can also play a protective role by c3 susceptible to factor i.
