Log in
HomeTextbook Notes300,000CA170,000

MICR 3230 Chapter : Chp 14 Cell-Mediated Cytotoxic Responses

40 views1 pages
greenfly526
22 Nov 2011
School
University of Guelph
Department
Microbiology
Course
MICR 3230
Professor
Azad Kaushik

For unlimited access to Textbook Notes, a Class+ subscription is required.

Document Summary

Ctls induce death via: perforin/granzyme pathway and fas/fasl pathway. Non-specific cytotoxic cells (nk cells, neutrophils, eosinophils, macrophages) also kill target cells. Cells bind the fc region of antibody on target cells and release lytic enzymes, perforin or tnf to damage membrane antibody-dependent cell-mediated cytotoxicity (adcc) Nk cells mediate lysis of tumor cells and virus infected cells by perforin-induced pore formation, similar to ctl mechanism. Nk cell receptors fall into: lectin-like or ig-like. Nk cell receptors transduce signals via itams(activating) or itims (inhibiting) High levels of class i mhc molecules on normal cells protects them against nk cell killing.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents

MICR 3230 Chapter Notes - Chapter 13+15: Tuberculin, Type Iii Hypersensitivity, Immunoglobulin G
coralraccoon960
PSL301H1 Chapter Notes -Cytotoxic T Cell, Mhc Class I, Antigen-Presenting Cell
champagneyak276
MIP 342 Lecture Notes - Intracellular Parasite, Immunoglobulin G, Tumor Necrosis Factor Alpha
lemondog142

Related Questions

Fill in the blanks below, using words from the supplied word bank (case-sensitive). Not all words will be used, and some may be used more than once.

When the naive helper T cells are initially activated on a ________, most differentiate into wither TH1 ot TH2 effector cells, depending mainly on the ________ in their environment. TH1 cells activate ________, ________, ________, while TH2 cells activate mainly ________. In both cases, the effector helper T cells recognize the same complex of foreign peptide and _______ protein on the target cell surface as they initially recognized on the ________ that activated them. They activate their _______ by a combination of membrane-bound and secreted co-stimulatory proteins. One membrane signal protein used by TH1 and TH2 cells is _____ lignad.

dendritic cell nuclei target cells class II MHC

cytotoxic T cells basophils B cells CD40

signal proteins macrophages dendritic cell cancer cells

Describe the steps of the cell-mediated immuneresponse, include the role of helper Tcells and how cytotoxic T cells work.

What are the functions of Class I and Class II MHCproteins?

Apply the above: how is the cell-mediated response involved infighting the rhinovirus infection?

With regards to cytotoxic T-cells, how are the activation requirements similar/different between mature naïve T-cells and CTL’s? Also, what differences in adhesion molecules and “effector” molecules may be present between the 2 groups?