MICR 3230 Chapter Notes - Chapter 13+15: Tuberculin, Type Iii Hypersensitivity, Immunoglobulin G
14 Mar 2016
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Neutralizaion: anibody binds part of pathogen that interacts with host proteins, inhibiing entry into the host cell. Opsonizaion: increase phagocytosis by making pathogen look tasty . Adcc (anibody-dependent cell-mediated cytotoxicity): direct cytotoxicity via fc receptors and ab"s *links amir and cmir. Recognize & kill infected/tumor cells via tcr acivaion. Signal 2: cosimulaion signal between t cell and apc. Ag presentaion to th1 by apc licensed apc. Licensed apc presents ag to pctl ctl. Ag presentaion to th1 and pctl at same ime ctl. Express cd40l (a tnf) that increases cosimulaion ligands, chemokines, cytokines - enhancing apc funcion. Cross presentaion: dc"s can present ag"s in mhc i and ii without being infected (just engulf it) opimal acivaion of t cells. Tc1: secrete ifn- but not il-4, use perforin and fas-mediated death inducion. Tc2: secrete il-4 (needs it to difereniate) and il-5, only use perforin death inducion. 4 idenical mhc bound to 4 pepides (luoresce when bound)
