MBG 2040 Chapter Notes - Chapter 7: Wild Type, Polytene Chromosome, Sex Linkage
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13 Oct 2017
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Linkage, crossing over, and chromosome mapping in eukaryotes. Early evidence for linkage and recombination: some of the first evidence for linkage came from experiments performed by w. In 1931 harriet creighton and barbara mcclintock obtained evidence that genetic recombination was associated with a material exchange between chromosomes. Key points: linkage between genes is detected as a deviation from expectations based on. Mendel"s principle of independent assortment: the frequency of recombination measures the intensity of linkage. Linkage analysis in humans: until the early 80s, progress in human gene mapping was extremely slow because it was difficult to find pedigrees that were segregating linked markers. Key points: linkage between human genes can be detected by analyzing pedigrees, pedigree analysis also provides of recombination frequencies to map genes on human chromosomes. Recombination and evolution: recombination can allow favourable alleles of different genes to come together in the same organism.
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