BIOM 3090 Chapter Notes - Chapter CARDIOVASCULAR: Angiotensin-Converting Enzyme, Sublingual Administration, Furosemide

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Elizabeth Campbell

Document Summary

Inhibit nacl transport in distal convoluted tubules: keeps the nacl in the dct, absorbed well orally, inexpensive and effective, toxicities: hypokalemia, gout (enhanced uric acid reabsorption), hyponatremia, furosemide. Inhibits co-transporter of na+, k+ and cl- in loop of henle. Inhibit nacl reabsorption to the surrounding vessels, keeps nacl in the loop: rapid, short acting, used mainly for severe hypertension and pulmonary edema (more powerful, toxicity: same as thiazide, clinical management of hypertension, na+ restriction, weight reduction, exercise. Sympatholytic/vasodilators: problems with combo therapy, lack of patient compliance, multiple medications to take, disease is asymptomatic, drugs are expensive, side effects are common, difficult to titrate fixed dose combos. Increasing sns (monitored by baroreceptors: renin angiotensin system, ventricular hypertrophy. If compensatory mechanisms return co to normal, the renal output will also return to normal. Ordinary physical activity does not cause undue fatigue, palpitation, or dyspnea: class ii, slight limitation of physical activity.