PHAR 100 Chapter Notes - Chapter 15: Angina Pectoris, Isosorbide Dinitrate, Lauder Brunton
11 Nov 2016
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Lesson c. 1 drugs for the treatment of angina pectoris and congestive heart failure. Describe the symptoms and causes of angina pectoris. Describe the mechanism of action of organic nitrates as antianginal agents. Describe the rationale for use of various organic nitrate preparations. Describe the therapeutic uses of organic nitrates. Describe the mechanism of action of beta-adrenergic blocking agents and calcium cannel blocking drugs as antianginal drugs. Describe the therapeutic uses of cardiac glycosides (digitalis) Describe the rational for measuring plasma levels of digoxin in patients. Angina pectoris choking pain in the chest. Usually caused by lipid deposits in the coronary arteries (atherosclerosis) hindering blood flow. Pain arises from diminished blood flow leading to lack of oxygen supplied to the heart muscles treatment increases the oxygen supply to deficient areas. Three major classes of antianginal drugs: (1) organic nitrates short-acting nitroglycerin, long-acting isosorbide dinitrate (2) -adrenergic antagonists prototype drug propranolol (3) calcium channel blockers prototype drug nifedipine.
