PHAR 100 Lecture 4: Lesson 4

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Jeanne Mulder, William Racz

Document Summary

Lesson 4. 1 (drugs for the treatment of angina pectoris) Angina pectoris first described by english physician heberden people who have it have a painful choking sensation in the chest during walking (usually uphill/after eating) but not when standing still. Amyl nitrite first introduced by brunton administered by inhalation = angina pain was relieved. 30-60 seconds, but action of the drug was transitory and lasted only 3-5 minutes; dosage difficult to adjust. Need for improved therapy murrell introduced sublingual nitroglycerin effect lasted 20-30 minutes. Choking pain in the chest due to lipid deposits in the coronary arteries hindering blood flow. Pain arises from diminished blood flow and diminished oxygen supply to area of the heart muscle. To reduce the pain, one must decrease the oxygen requirement of the heart and/or increase the oxygen supply to deficient areas of the heart muscle. Eating, exercise, excitement and exposure to cold increase the oxygen demand on the heart muscle.