BIOLOGY 3UU3 Chapter Notes - Chapter 12: Exon, Hypothalamus, Consensus Sequence
13 Apr 2017
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Reversal of maternal programming of stress responses in adult offspring through methyl. Hypothalamic-pituitary-adrenal (hpa) response to stress: inducible defence activated upon to threat: magnitude of response is related to hypothalamic corticotrophin-releasing factor (crf) that activates pituitary-adrenal system, synthesis and release of crf is inhibited by glucocorticoid-negative feedback. Offspring from mothers that exhibit high level of puplicking/grooming and arched-back nursing activity (high. => this result in demethylation: suggest that maternal behaviour can directly affect defensive response to stress. Lg-abn offspring and rarely in high lg-abn offspring: contrast to cytosine at 3"cpg dinucleotide, which is always methylated and independent of high/low. Step 3: effect of methionine on hpa response to stress: plasma corticosterone response (hpa response) to stress is higher with increased methylation of the ngfi-a consensus sequence and down-regulation of gr. Intracellular level of methionine seem to be affected by both dietary intake and polymorphism of enzymes involved in metabolism, such as methylenetetrahydrofolate-reductase.
