BIOC14H3 Lecture Notes - Lecture 9: Glucocorticoid, Non-Coding Rna, Epigenome
25 Apr 2013
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Bioc14winter2013 lecture 9: environmental epigenetics and transgenerational epigenetic inheritance. The histone code: covalent modifications of the n terminal tail of histones. The stress response the hpa axis: a negative feedback loop. Increased gr = decreased stress response the stress response v v v v the hpa axis: a negative feedback loop. Glucocorticoid receptors (grs): bind glucocorticoids and inhibit the stress response. Sites for abused suicide person than non abused and control. Summary: gr promoter is hypermethylated and expression reduced in the hippocampus of suicide victims with a history of child abuse, the data suggest that childhood abuse confers additional risk for suicide through epigenetic changes involved in stress response. Epigenetic regulation of the gr gene in human brain expression methylation 0510152025303540451234567891011121314151617181920212223242526272829303132333435363738cpg sitemethylation (freq. The epigenetic response to early environment varies across gene elements. Changes in dna methylation are correlated across 1 million base pairs of dna.
