CHEM 271 Chapter Notes - Chapter 6: Statistical Significance, Myoglobin, Protein Structure
16 Apr 2016
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Chapter 6 exploring evolution and bioinformatics (excludes 6. 5) Homologous molecules (homologs) can be divided into two classes: Paralogs are homologs that are present within one species. Orthologs are homologs that are present within diferent species and have very similar or idenical funcions. Homology is oten detectable by signiicant similarity in nucleoide or amino acid sequence and almost always manifested in three-dimensional structure. Staisical analysis of sequence alignments can detect homology. Sequence alignment: two sequences are systemaically aligned with resprect to each other to idenify regions of signiicant overlap. Simplest approach: slide one sequence past the other and count the number of sequence ideniies. Inserions of gaps allows the alignment method to compensate for the inserions or deleions of nucleoides that may have taken place in the gene for one molecule but not the other in the course of evoluion. However, the use of gaps may generate ariicial similariies.
