01:694:301 Lecture Notes - Lecture 6: Gene Duplication, Cell Nucleus, Railways Act 1921
14 Nov 2018
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The proteins have different roles in the body but obviously have common ancestor: refer fig. Here the duplication event (hb/mb) too place 100s myo, but speciation event (human/chip) took place 6 myo: homology is often detectable by significant similarity in nucleotide or amino acid sequence and almost always manifested in three-dimensional structure. Slide one sequence past another one amino acid at a time, count the # matched residues sequence identities". Insertion of gaps compensates for insertions or deletions of nucleotides for one gene not the other over evo. After repeating this process, compare the original scores with new scores. 6. 9 blosum matrix: two proteins related by evo undergo amino acid substitution as they diverge. Scoring system does not take this into account. Thus methods were created to assess degree of similarities b/w aa: creation of substitution matrices, not all substitution are equivalent.
