PHM PRAC 656 Study Guide - Final Guide: Ace Inhibitor, Lisinopril, Beta Blocker
Document Summary
Is lisinopril the most safe and effective means for the treatment of hypertension in african. Lisinopril, as a first-line monotherapy is not indicated for an african american hypertensive patient due to the availability of safer and more efficacious alternatives (i. e. thiazide diuretics). Hg reduction overall in dbp. 2 this efficacy rate corresponds favorably with the results generated in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (allhat) studies. 1. From february 1994 through march 2002 allhat, a randomized, double-blind, active- controlled, clinical outcome study involving 33,357 patients age 55 or older of which 35% were. Moreover, randomization of african american patients to lisinopril vs. chlorthalidone significantly increased the risk of stroke (rr, 1. 40; 95% ci, 1. 17-1. 68), and combined cvd (rr 1. 19; 95% ci 1. 09-1. 30). Importantly, these differences in rates of stroke and cvd were normalized to the variable rates of bp reduction seen between the therapeutic classes. 2.
