PCD 8117 Final: 1 exam 2 cariology (8)
3 Jan 2020
School
Department
Course
Professor
swallow;
IgA
Lecture #8 - Cariology Vaccines
1.
Know the basic assumptions that accompany design of a caries vaccine.
o Is caries vaccine necessary?
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Caries is a non-life-threatening disease, so safety issues very important.
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Vaccine would not be 100% protective and targeting high risk population
may be perceived negatively.
o Is a vaccine feasible?
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Would be likely protective to some degree, but uncertain how much.
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Behavioral choices still provides protective effects.
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Too vigorous of an immune response (vaccine) can be just as bad as too
little a response.
▪
Additionally, still unsure of how much a role S. mutans plays in caries.
o Assumptions for vaccine development – S. mutans and/or S. sobrinus are the most
prominent cause of dental caries.
o Immune response
▪
Salivary prevents adherence of S. mutans by aggregating it for
different than normal role of phagocytes.
▪
If an antibody is protective against caries, then those who are caries free
must have higher levels of the antibody against S. mutans – however, there
is no difference among test populations.
2.
Know the options, strengths, and weaknesses of different study designs.
