NSCI430- Midterm Exam Guide - Comprehensive Notes for the exam ( 20 pages long!)
12 Oct 2017
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66a: benefits of studying aplysia, habituation, sensitization, classical conditioning, lower order animal, habituation, if you touch the siphon enough times you get a decrease in glutamate onto the. Integrative neuroscience chapter 44: major degenerative diseases, alzheimers, parkinson, triplet-repeat (huntington, spinocerebellar ataxias, sporadic: alzheimer"s and parkinson c. Inherited: triplet-repeat diseases: expanded trinucleotide repeats, huntington disease a. i. Degeneration of the striatum (mostly caudate nucleus) a. i. 1. Loss of medium spiny neurons (inhibitory interneurons) inhibits subthalamic nucleus choreiform movements a. i. 2. Loss of motor control a. ii. 1. a. ii. 2. a. ii. 3. a. ii. 4. Expansion of translated cag repeat encodes glutamine tract in huntingtin protein a. v. 1. a. Huntington disease-like 2: ctg expansion in junctophilin 3. Huntingtin protein: expressed throughout the brain in the cytoplasm a. v. 3. a. Associates with microtubules: spinobulbar muscular atrophy (kennedy disease) b. i. Expansion of cag repeat in androgen receptor protein b. iii. Only males show symptoms requires androgen b. iv. Symptoms: resting tremor, bradykinesia, rigidity, impairment in movement, mask-like expressionless appearance c. ii.
