MCD BIO 138 Study Guide - Final Guide: Small Interfering Rna, Commissure, Morphogen
15 Dec 2016
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Hox genes - regionalization of tube in hindbrain/posterior. Anr/mhb - fgf8 - regionalization of tube in anterior brain. Bmp (dorsal) and shh (ventral) opposing gradients pattern neural tube. Birds/mammals: ingression, germ layers not specified, flat sheet. Bmp antagonists -> notochord + neural plate formation. Bmp activity gradient (dorsal blastopore lip) nieuwkoop center = posterior marginal zone. High wnt/b cat -> high nodal -> meso formation. Exp + results that show temporal order of somite formation. Transplant older posterior somite to anterior younger embryo -> posterior identity forms in the young embryo. Fgf role in somite formation + clock/wavefront model. When fgf regresses w/ node - presomitic mesoderm is allowed to form somite. Compartment def + function independent developmental units, region of cell-lineage restriction. Hox gene boundary is the same as each rhombomere boundary. Exp + results show fgf8 role in anterior forebrain development and patterning. Cre/loxp knocks out receptors in forebrain -> cells don"t respond to.
