BIO SCI E124 Study Guide - Midterm Guide: Apoptosis, Weak Interaction, Mhc Class Ii
Document Summary
Helper t cell interacts with apc through recognition of mhc ii + ag. Apc needs to be activated by helper t cell by tcr recognition. Now the apc can activate the ctl (only b/c of mhc i) Ag inside infected cell is cleaved into smaller pieces. Infected cell: proteolysis - viral ag cleaved into small fragments, 8 - 10 aas long. Chopped up antigen fragments are then sent to er from cytosol, where the assembly. Done by tap: transporter associated with ag processing. Ctl recognizes ag + mhc i as apc, activating ctl. loop. Mhc i is assembled in er- brought in close proximity with tap. Tap + tapasin
