BIO SCI 98 Study Guide - Final Guide: Cholesterol, Phenylalanine, Carbamoyl Phosphate
25 Apr 2016
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Preparatory phase- phosphorylation of glucose g3p. Irreversible steps: hk (hexokinase, pfk1 (phosphofructokinase, pk (pyruvate kinase) Mg2+ is needed to help convert adp into good leaving group. Pgk, pgm, and pk (6 steps actually use mg2+) Hk step of glycolysis converts terminal oh opo. This generates a c=n bond to split c3 and c4 of. Substrate level phosphorylation occurs in pgk and pk. Definition- to make glucose from 3-4 carbon precursors. Major sources: lactate/ amino acids/ propionate/ glycerol. Cori cycle- turns lactate to glucose then transport it to muscles, results in 6 net atp: lactate- transported from muscle to liver, glucose-transported from liver to muscle. Lance armstrong-had high vo2 max and could produce a lot of glucose. Gluconeogenesis needs to bypass 3 irreversible steps. Pepck- mighty mouse enzyme that made the mouse have greater endurance. Malate- allows oaa to change form to be transported from the mitochondrial matrix to cytosol.
