PMY 302 Study Guide - Midterm Guide: Hydrocodone, Pharmacology, Naloxone
17 May 2016
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Pain pathways and site of drug action, analgesics, nsaids like aspirin: decrease chemical reactions of stimuli, opioids: bind to r inside neurons enkephalin, body natural pain killer, nsaids vs. analgesics. Nsaid: good for acute pain, acetaminophen, decrease inflammation, block. Analgesics: opioids agonists, alpha2-adrenergic agonist, not lower inflammation: major pharmacologic effects of opiod agonists, cns: analgesia (the only therapeutic effect), miosis, respiratory depression, cardiovascular: decreased o2 demand, vasodilation and hypotension, gi: constipation, urinary retention, opioids, 3 classes. Opium: addictive narcotic rug, consists of dried juice of opium poppy. Opioids: any narcotic analgesic substances, natural or synthetic. Synthetic: hydrocodone, oxycodone, meperidine, propoxyphene, fentanyl, heroin, methadone: opioid receptors. The mu receptor is the principle mediator of opioid-induced analgesia. Found in cns, peripheral sensory nerves, gi: tolerance, dependence and addiction. Develops o analgesia, euphoria, respiratory depression, not constipation and miosis. Addiction: psychological, take drugs when not medically necessary. Opioids are mainly schedule ii, high abuse potential and severe dependence liability: strong opioid agonists.
