PHA 3112 Study Guide - Midterm Guide: Opioid Overdose, Opioid Antagonist, Cocaine Dependence

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Pierre Fortier

Document Summary

Classification of drugs that at @ opiod receptors: pure opiod agnoist: produce analgesia, euphoria, sedation, respiratory depression, Act on mu & kappa receptors as agonist promotion of pain reflief: agonist-antagonist opiod/partial agonist: produce analgesia alone. Low potential of abuse, less respiratory depression, less powerful analgesic effects. Drugs: pentazocine (mu: antagonist & kappa: agonist), nalbuphine (mu: antagonist & kappa: agonist), butorphanol (mu: antagonist & kappa: agonist), buprenorphine (mu: partial agonist, kappa: antagonist): pure opiod antagonist: don"t produce analgesia/effects caused by opioid agonist. Use for treatment: reversal of respiratory & cns depression caused by overdose w/opiod. All 3 act as antagnoists for mu & kappa receptors. Drug interactions: don"t combine with meperidine with monoamine oxidase (mao) inhibitor. Wd signs: excessive crying, sneezing, tremor, hyperreflexia, fever, & diarrhea. Moderate to strong opioids: produce less analgesia & respiratory depression than morphine, and lower potential for abuse: codeine: oral administration; produce significant pain relief & greater w/ combo of nonopioid analgesic.