MIC 401 Study Guide - Midterm Guide: Growth Medium, Salmonella Enterica, Facultative Anaerobic Organism
30 Mar 2016
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Document Summary
Lps consists of o polysaccharide side-chains: lipopolysaccharide, in outer membrane, used for serotyping strains. Salmonella shigella agar selecive growth medium for gram (-) bile salts (inhibit gm+) Fermentaion, sugar uilizaion: lactose, neutral red (ph), use of lactose acid. Lipopolysacchirides o anigens: > 2400 o serotypes (ab-speciic) Salmonella invade the intesinal epithelial cells to iniiate infecion. Mode of infecion: oral entry and usually limited to intesine (non- disseminated) Mode of infecion: oral and invades intesines but desseminates from intesine to other organs systemic. Reinvasion of the intesinal epithelium (hemorrhagic ulceraion) Chronic (asymptomaic) carriage in gall bladder; shedding into the intesine typhoid mary . Genes required for salmonella to cause disease virulence genes clustered in the chromosome in a pathogeneciiy island 1 (spi-1) Sip/ssp proteins (efectors) are injected into the host cell and simulate the uptake of bacterium into the host cell. Spi-2 survival of salmonella in the cytoplasm.
