MMI133 Lecture Notes - Lecture 19: Staphylococcus, Salmonella Enterica, Shigella Dysenteriae
2 Feb 2017
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Mmi 133 session 19 lower alimentary tract infections. Proper food preparation and handling: predominant flora of the intestine. Diseases of the gi tract are of 2 types: infections: Pathogen multiplies in mucosa or passes through to other systemic organs. Characterized by fever, release of endotoxin (lps: intoxications: Usually sudden onset and no fever or other systemic symptoms: result of both: diarrhea. Main pathogenic mechanisms of lower alimentary tract pathogens: attachment, cell invasion, loss of microvilli, exotoxin production: 2 basic actions of exotoxin on the gut. 1) increase secretion of water and electrolytes ie: vibrio cholera enterotoxin. 2) inhibit protein synthesis and cause cell death: rmr: many gi pathogens are gram and have both endotoxins and ie: clostridium difficile cytotoxin exotoxins, dysentery: Severe diarrhea with blood, often pus and or mucus. Ie: e. histolytica (amoeba), shigella dysenteriae (bacteria: gastroenteritis. Inflammation of the stomach and the intestinal mucosa, no.
