GENE 540 Midterm: Centrosome Replication
Document Summary
Here you have the process for centrosome replication. Separase disengages the centrioles it is only active at anaphase (centrioles come apart no longer in the perpendicular fashion) Separase separated the duplicated chromosomes at metaphase via breaking the cohesion subunits this leads to anaphase. Only disengaged centrioles can replicate what makes them start to replicate is the. Cdk2/cyclin e that is only active during the s-phase. Licensing is an event it is essentially separase disengaging the centrioles. Then the new centrioles synthesized are engaged tightly associated; this means that separase is not present at this step. Now we are going to be talking about signals to tell the cell to stop proliferating (arrest cell division) Tgfb transforming growth factor beta it induces g1 arrest in some cell types. You can even add this to serum starved cells; where if you add the serum first and then tgfb, the cells will go into g0 arrest.
