PSY-B - Psychology PSY-B 394 Study Guide - Final Guide: Gabaa Receptor, Bulgarian State Railways, Anxiety Disorder

• School: IUPUI
• Department: PSY-B - Psychology
• Course: PSY-B - Psychology PSY-B 394
• Professor: Boehm

Document Summary

Anxiety disorder review 2: neurochemical/anatomical basis of anxiety & anxiolytics. Gabaa receptor: classic cns depressants alter gabaa receptor function, bdzs enhance effects of gaba on cl- ion flux increase frequency of channel openings, benzodiazepines increase cl- conductance: effect blocked by bdz antagonist. Gabaa-bdzs receptors & anxiety disorders: evidence of decreased bdz-sensitive gabaa receptors in patients w/ anxiety disorder. Reduced gabaa-bdz receptor binding in patients w/ anxiety disorders (neuroimaging studies) Pharmacologic challenge studies also suggest gad, ocd, & panic disorder associated w/ sub- sensitive receptors (benzo binding sites: anxiolysis through gabaa-bdz receptors. Strong correlation between anxiolytic potencies of various bdzs & ability to displace 3hdiazepamm from bdz receptors in vitro (snri"s and ssri"s w/ neurocircuitry [lc and norepinephrine]: bdz receptor is allosteric modulatory site on gabaa receptor. Bdzs enhance effects of gaba, bind at difference site on receptor (positive allosteric modulators) Antagonists bind to bdz binding site (block ability of bdzs to amplify effect of gaba)