PSYC 3030 Lecture Notes - Lecture 18: Striatum, Protein Precursor, Area Postrema
12 Dec 2016
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Sedative hypnotics (relaxing/sleep producing) drugs with anxiolytic, muscle relaxant, and anticonvulsant effects. The effects of bdzs are mediated by increasing gaba- stimulated flow of cl- across the cell membrane (increasing the rate of channel opening) No effect on their own in the absence of gaba site. Can increase the affinity of gaba at it"s binding. Antagonists: ro15-1788, given to patients who become drowsy after procedures involving bdzs. Beta carboline drugs (beta cce, beta ccm, dmcm) Inverse agonists: bind to the same site, not the same as antagonists. Turn down the effects of gaba, but the overall effect of. Similar to endogenous compounds found in the urine of anxious individuals, they produce anxiety and seizures at higher doses. Those binding sites have not evolved for drugs, but for endogenous ligands. There are some cases where the endogenous ligands have not been identified. Decrease conductance of cl- when gaba binds (opposite effect of agonists) Similar to bdzs and barbiturates, enhances inhibitory effects.
